{"created":"2024-03-05T05:38:55.514278+00:00","id":2012699,"links":{},"metadata":{"_buckets":{"deposit":"12be8db7-00e4-4ee9-b834-da066e359de4"},"_deposit":{"created_by":9,"id":"2012699","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2012699"},"status":"published"},"_oai":{"id":"oai:our.repo.nii.ac.jp:02012699","sets":["1623632832836:1707978071892","1707979148924:1707983962284"]},"author_link":[],"item_30002_access_rights4":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_30002_creator2":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川島, 隆史","creatorNameLang":"ja"},{"creatorName":"カワシマ, タカフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawashima, Takafumi","creatorNameLang":"en"}]}]},"item_30002_date11":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-01-01","subitem_date_issued_type":"Issued"}]},"item_30002_date_granted32":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2021-12-21"}]},"item_30002_degree_grantor33":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"大分大学"}]}]},"item_30002_degree_name31":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_30002_description9":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Introduction/aims: Lymphatic vessels are responsible for the removal of metabolic waste from body tissues. They also play a crucial role in skeletal muscle functioning thorough their high-energy metabolism. In this study we investigated whether disuse muscle atrophy induced by hindlimb unloading is associated with an alteration in the number of lymphatic vessels and differential expression of lymphangiogenic factors in the soleus muscle.","subitem_description_language":"en"},{"subitem_description":"Methods: Male C57BL/6 mice were subjected to tail suspension (TS) for 2 or 4 weeks to induce soleus muscle atrophy. After TS, lymphatic and blood capillaries in the soleus muscle were visualized and counted by double staining with LYVE-1 and CD31. The protein and mRNA levels of vascular endothelial growth factor (VEGF)-C, VEGF-D, and vascular endothelial growth factor receptor-3 were measured by Western blotting and real-time reverse transcript polymerase chain reaction, respectively.","subitem_description_language":"en"},{"subitem_description":"Results: TS for 2 weeks resulted in a significant decrease in the number of blood capillaries compared with controls. However, there was no significant change in the number of lymphatic capillaries. By contrast, TS for 4 weeks resulted in a significant decrease in the number of lymphatic and blood capillaries. We observed a significant decrease in the mRNA levels of VEGF-C and VEGF-D in mice subjected to TS for 4 weeks.","subitem_description_language":"en"},{"subitem_description":"Discussion: The decrease of intramuscular lymphatic vessels may a crucial role in the process of muscle atrophy.","subitem_description_language":"en"}]},"item_30002_dissertation_number30":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第674号"}]},"item_30002_identifier16":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/10559/16912"}]},"item_30002_language12":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_publisher10":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"大分大学","subitem_publisher_language":"ja"}]},"item_30002_relation18":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/mus.27402","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_30002_title0":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading","subitem_title_language":"en"},{"subitem_title":"後肢免荷によるマウスヒラメ筋内リンパ管の組織学的および生化学的変化","subitem_title_language":"ja"}]},"item_title":"Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading","item_type_id":"30002","owner":"9","path":["1707983962284","1707978071892"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-01-13"},"publish_date":"2022-01-13","publish_status":"0","recid":"2012699","relation_version_is_last":true,"title":["Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-03-18T05:43:25.105087+00:00"}