WEKO3
アイテム
後肢免荷によるマウスヒラメ筋内リンパ管の組織学的および生化学的変化
http://hdl.handle.net/10559/16912
http://hdl.handle.net/10559/16912547aac25-cdb4-4fe4-8fd2-63dbca01fc8b
| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2022-01-13 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 後肢免荷によるマウスヒラメ筋内リンパ管の組織学的および生化学的変化 | |||||||||||
| 言語 | ja | |||||||||||
| 作成者 |
川島, 隆史
× 川島, 隆史
|
|||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Introduction/aims: Lymphatic vessels are responsible for the removal of metabolic waste from body tissues. They also play a crucial role in skeletal muscle functioning thorough their high-energy metabolism. In this study we investigated whether disuse muscle atrophy induced by hindlimb unloading is associated with an alteration in the number of lymphatic vessels and differential expression of lymphangiogenic factors in the soleus muscle. | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Methods: Male C57BL/6 mice were subjected to tail suspension (TS) for 2 or 4 weeks to induce soleus muscle atrophy. After TS, lymphatic and blood capillaries in the soleus muscle were visualized and counted by double staining with LYVE-1 and CD31. The protein and mRNA levels of vascular endothelial growth factor (VEGF)-C, VEGF-D, and vascular endothelial growth factor receptor-3 were measured by Western blotting and real-time reverse transcript polymerase chain reaction, respectively. | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Results: TS for 2 weeks resulted in a significant decrease in the number of blood capillaries compared with controls. However, there was no significant change in the number of lymphatic capillaries. By contrast, TS for 4 weeks resulted in a significant decrease in the number of lymphatic and blood capillaries. We observed a significant decrease in the mRNA levels of VEGF-C and VEGF-D in mice subjected to TS for 4 weeks. | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Discussion: The decrease of intramuscular lymphatic vessels may a crucial role in the process of muscle atrophy. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 大分大学 | |||||||||||
| 言語 | ja | |||||||||||
| 日付 | ||||||||||||
| 日付 | 2021-01-01 | |||||||||||
| 日付タイプ | Issued | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| 識別子 | ||||||||||||
| 識別子 | http://hdl.handle.net/10559/16912 | |||||||||||
| 識別子タイプ | HDL | |||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1002/mus.27402 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第674号 | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士(医学) | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2021-12-21 | |||||||||||
| 学位授与機関 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大分大学 | |||||||||||
